Daria Mochly-Rosen Selected Research

Reperfusion Injury

2/2022	A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury.
1/2016	Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury.
1/2015	Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1.
9/2014	Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.
4/2010	Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.
2/2009	Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2.
6/2007	Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury.
12/2005	The role of protein kinase C in cerebral ischemic and reperfusion injury.
5/2005	Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.
11/2004	Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria.

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Daria Mochly-Rosen Research Topics

Disease

29	Ischemia 01/2016 - 06/2002
21	Myocardial Infarction 02/2022 - 08/2006
18	Neoplasms (Cancer) 10/2022 - 05/2002
16	Reperfusion Injury 02/2022 - 08/2003
15	Heart Failure 10/2019 - 10/2002
11	Inflammation (Inflammations) 01/2022 - 10/2007
11	Infarction (Infarctions) 10/2013 - 11/2003
10	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 11/2011
8	Pain (Aches) 11/2021 - 05/2004
6	Glucosephosphate Dehydrogenase Deficiency 01/2022 - 06/2016
6	Hypertension (High Blood Pressure) 07/2012 - 10/2002
6	Cardiomegaly (Heart Hypertrophy) 10/2011 - 10/2002
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2012
5	Flushing 01/2022 - 02/2010
5	Huntington Disease (Huntington's Disease) 01/2018 - 12/2013
5	Stroke (Strokes) 01/2017 - 07/2003
4	Fibrosis (Cirrhosis) 03/2021 - 01/2008
4	Heart Diseases (Heart Disease) 03/2015 - 01/2008
4	Hypertrophy 10/2011 - 10/2002
4	Brain Ischemia (Cerebral Ischemia) 12/2005 - 07/2003
3	COVID-19 01/2022 - 01/2021
3	Hemolytic Anemia 01/2022 - 10/2018
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 01/2014
3	Myocardial Ischemia (Ischemic Heart Diseases) 09/2013 - 02/2007
3	Coronary Artery Disease (Coronary Atherosclerosis) 05/2005 - 01/2004
2	Carcinogenesis 02/2022 - 05/2002
2	Communicable Diseases (Infectious Diseases) 01/2022 - 01/2021
2	Atrial Fibrillation 01/2021 - 12/2016
2	Brain Diseases (Brain Disorder) 01/2020 - 01/2011
2	Sepsis (Septicemia) 01/2020 - 01/2019
2	Alzheimer Disease (Alzheimer's Disease) 12/2019 - 12/2016
2	Cardiomyopathies (Cardiomyopathy) 01/2019 - 01/2015
2	Head and Neck Neoplasms (Head and Neck Cancer) 12/2018 - 08/2013
2	Xerostomia 12/2018 - 08/2013
2	Squamous Cell Carcinoma of Head and Neck 01/2018 - 08/2017
2	Cardiotoxicity 01/2018 - 11/2011
2	Diabetes Complications 01/2018 - 12/2012
2	Parkinson Disease (Parkinson's Disease) 12/2016 - 02/2013
2	Heart Arrest (Cardiac Arrest) 01/2016 - 06/2005
2	Brain Injuries (Brain Injury) 06/2013 - 07/2003
2	Angina Pectoris 01/2012 - 11/2011
2	Prostatic Neoplasms (Prostate Cancer) 06/2011 - 08/2008
2	Atherosclerosis 01/2010 - 01/2008
2	Hyperglycemia 01/2009 - 10/2005
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 12/2008 - 10/2002

Drug/Important Bio-Agent (IBA)

23	Protein Kinase CIBA 10/2011 - 06/2002
20	AldehydesIBA 10/2022 - 09/2008
20	Proteins (Proteins, Gene)FDA Link 03/2021 - 05/2002
19	Peptides (Polypeptides)IBA 02/2022 - 08/2003
17	IsoenzymesIBA 09/2013 - 05/2002
16	Aldehyde DehydrogenaseIBA 12/2019 - 02/2009
12	EnzymesIBA 10/2022 - 07/2005
9	Phosphotransferases (Kinase)IBA 02/2022 - 11/2003
7	Ethanol (Ethyl Alcohol)IBA 12/2019 - 08/2005
6	Pharmaceutical PreparationsIBA 10/2022 - 02/2008
6	delta proteinIBA 02/2022 - 11/2003
6	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 01/2022 - 06/2016
6	Protein Kinases (Protein Kinase)IBA 06/2013 - 11/2004
6	Protein Kinase C-epsilonIBA 10/2005 - 05/2002
5	Amino Acids FDA Link 02/2022 - 08/2006
5	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 11/2021 - 04/2010
5	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 07/2004
5	SaltsIBA 12/2008 - 10/2002
4	Oxidoreductases (Dehydrogenase)IBA 10/2022 - 07/2005
4	AcetaldehydeIBA 02/2022 - 02/2010
4	Oxygen (Dioxygen)IBA 06/2005 - 12/2003
3	Protein Isoforms (Isoforms)IBA 10/2022 - 06/2002
3	Protein Kinase C-deltaIBA 02/2022 - 08/2004
3	VaccinesIBA 01/2022 - 01/2021
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 02/2008
3	Adenosine Triphosphate (ATP)IBA 12/2018 - 10/2013
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 02/2013
3	polyglutamineIBA 11/2016 - 01/2014
3	Huntingtin ProteinIBA 11/2016 - 12/2013
3	Neuroprotective AgentsIBA 01/2015 - 12/2005
3	Mitochondrial Aldehyde DehydrogenaseIBA 09/2014 - 10/2010
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2012 - 01/2008
2	IgYIBA 01/2022 - 01/2021
2	LipopolysaccharidesIBA 01/2021 - 01/2020
2	Dynamins (Dynamin)IBA 01/2020 - 01/2019
2	BilirubinIBA 10/2018 - 06/2016
2	Cisplatin (Platino)FDA LinkGeneric 08/2017 - 05/2017
2	Biological ProductsIBA 12/2016 - 06/2011
2	CalciumIBA 01/2016 - 01/2016
2	Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA 10/2015 - 06/2013
2	Therapeutic UsesIBA 01/2015 - 12/2008
2	Analgesics (Analgesic Drugs)IBA 08/2014 - 01/2014
2	Opioid Analgesics (Opioids)IBA 01/2014 - 07/2004
2	BradykininIBA 09/2013 - 04/2009
2	Nitroglycerin (Dynamite)FDA LinkGeneric 01/2012 - 11/2011
2	Formaldehyde (Formol)FDA Link 08/2011 - 05/2004
2	tat Gene Products (tat Protein)IBA 10/2010 - 08/2003
2	Creatine Kinase (Creatine Phosphokinase)IBA 02/2009 - 08/2003
2	Receptors for Activated C KinaseIBA 01/2009 - 10/2005
2	dimemorfan (AT 17)IBA 06/2008 - 10/2002
2	Cytochromes c (Cytochrome c)IBA 08/2007 - 06/2005

Therapy/Procedure

10	Therapeutics 10/2022 - 01/2007
3	Radiotherapy 12/2018 - 07/2012
2	Intraperitoneal Injections 02/2009 - 05/2007
2	Heart Transplantation (Grafting, Heart) 10/2007 - 09/2004